Search results for "Meibomian gland dysfunction"

showing 8 items of 8 documents

The human meibomian gland epithelial cell line as a model to study meibomian gland dysfunction

2016

The meibomian gland dysfunction (MGD) is the leading cause of dry eye disease (DED) throughout the world. The investigation of MGD lacks suitable in vivo and in vitro models. In 2010 a human meibomian gland epithelial cell line (HMGEC) was established, so far the only available meibomian gland cell line. The characterization of HMGEC is of major importance to clarify its suitability for studying the meibomian gland (patho)physiology in vitro. The current culture protocol and new concepts of HMGEC culture will be compared. Hormones are believed to be a key factor in meibomian gland dysfunction thus HMGEC responsiveness to hormone stimulation is crucial to elucidate the hormonal influence on …

0301 basic medicinePathologymedicine.medical_specialtyMeibomian glandBiologyModels BiologicalCell Line03 medical and health sciencesCellular and Molecular NeuroscienceHormone stimulation0302 clinical medicinestomatognathic systemRisk FactorsmedicineHumansGonadal Steroid HormonesCells Culturedintegumentary systemMeibomian gland dysfunctionMeibomian GlandsEpithelial CellsSensory SystemsEpitheliumAnti-Bacterial Agentsbody regionsOphthalmology030104 developmental biologymedicine.anatomical_structure030221 ophthalmology & optometryDry Eye Syndromessense organsOphthalmic SolutionsHormoneExperimental Eye Research
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Chambered warm moist air eyelid warming devices – a review

2021

Background Eyelid warming is an important treatment for meibomian gland dysfunction (MGD). Specialized chambered devices, using warm moist air have been developed. Purpose To critically evaluate the literature on the safety and efficacy of chambered warm moist air devices in MGD treatment and pinpoint areas of future research. Methods PubMed and Embase were searched on 06 June 2021. The search term was ‘(warm OR heat OR steam OR goggle OR spectacle OR moist air) AND (meibomian OR MGD OR blepharitis OR eyelid OR dry eye OR DED)’. All relevant articles with available English full text were included. Results Eighteen articles assessing the application of chambered warm moist air eyelid warming…

medicine.medical_specialtyWarm moist airGeneral PracticeSigns and symptomsoppvarming av øyelokkreviewartikkeleyelid warming devicesDry eye diseasesPrimary outcomeVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754MedicineHumansBlepharitisBlephasteamwarm moist airBlephasteam; dry eye disease; eyelid warming devices; meibomian gland dysfunction; warm moist airEyelid warming devicesbusiness.industryMeibomian gland dysfunctionMeibomian GlandsøyelokkGeneral Medicinemeibomian gland dysfunctionmedicine.diseaseMeibomian gland dysfunctiondry eye diseaseeye diseasesSurgeryAllmänmedicinOphthalmologySteammedicine.anatomical_structureSymptom improvementTreatment studyTearsDry heatEyelid DiseasesDry Eye SyndromesEyelidsense organsbusiness:Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754 [VDP]
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Silto acu komprešu ietekme uz acs asaru slāņa īpašībām

2021

Pētījuma mērķis bija novērtēt silto komprešu terapijas efektivitāti uz asaru slāņa īpašībām pacientiem ar sausas acs subjektīvo simptomātiku. 18 pētījuma dalībniekieki, lietojot TheraPearl acu maskas divas reizes dienā no rīta un vakarā pa 5 vai 10 minūtēm, veica silto komprešu terapiju 14 dienu periodā. Diagnostikie mērījumi pirms terapijas, pēc terapijas un trīs nedēļas pēc terapijas beigām tika veikti asaru slāņa īpašību novērtēšanai. Dalībnieki pēc terapijas uzrādīja ievērojamu OSDI un DEQ-5 anketu rezultāta uzlabošanos un uzlabojums saglabājās arī trīs nedēļas pēc terapijas beigām. Pēc terapijas netika novērots statiski būtisks uzlabojums neinvazīvajā asaru slāņa plīšanas laikā (NIBUT).

warm compress therapyFizikameibomian gland dysfunctiondry eye symptomswarm compressdry eye disease
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Topical glaucoma medications – Clinical implications for the ocular surface

2022

Glaucoma is a leading cause of irreversible blindness. The use of topical eye drops to reduce intraocular pressure remains the mainstay treatment. These eye drops frequently contain preservatives designed to ensure sterility of the compound. A growing number of clinical and experimental studies report the detrimental effects of not only these preservatives but also the active pharmaceutical compounds on the ocular surface, with resultant tear film instability and dry eye disease. Herein, we critically appraise the published literature exploring the effects of preservatives and pharmaceutical compounds on the ocular surface. publishedVersion

Oorganisk kemiPreservatives PharmaceuticalGlaucomaMeibomian gland dysfunctionInorganic ChemistryOphthalmologyVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754:Medisinske Fag: 700 [VDP]TearsTopical medicationsHumansEyedropsDry Eye SyndromesDry eye diseaseOphthalmic SolutionsDry eye disease; Eyedrops; Glaucoma; Meibomian gland dysfunction; Topical medicationsAntihypertensive AgentsIntraocular Pressure
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Hot towels

2023

Background Meibomian gland dysfunction (MGD) reduces quality-of-life and hinders work productivity of millions of patients, with high direct and indirect societal costs. Thickened meibum obstructs the glands and disrupts ocular surface health. Heating the eyelids to soften and express meibum from the glands can be beneficial. The most accessible method for eyelid warming uses heated, wet towels. However, the efficacy of this treatment is reliant on the methodology, and evidence-based best-practice recommendations are needed. Purpose To evaluate the literature on hot towels in MGD treatment and recommend a best-practice protocol for future research and patient treatment. Methods Studies were…

OphthalmologyEyelid warmingVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754:Medisinske Fag: 700 [VDP]Evaporative dry eyeHot towelsGeneral MedicineDry eye diseaseMeibomian gland dysfunctionOptometryContact Lens and Anterior Eye
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Diagnostic Capability of a New Objective Method to Assess Meibomian Gland Visibility

2021

SIGNIFICANCE The diagnosis of dry eye disease and meibomian gland dysfunction (MGD) is challenging. Measuring meibomian gland visibility may provide an additional objective method to diagnose MGD. PURPOSE This study aimed to evaluate the ability of new metrics to better diagnose MGD, based on measuring meibomian gland visibility. METHODS One hundred twelve healthy volunteers (age, 48.3 ± 27.5 years) were enrolled in this study. Ocular surface parameters were measured using the Oculus Keratograph 5M (Oculus GmbH, Wetzlar). Subjects were classified according to the presence or absence of MGD. New metrics based on the visibility of the meibomian glands were calculated and later compared betwee…

Adultmedicine.medical_specialtyMeibomian glandPixel intensityLogistic regressionYoung AdultOphthalmologyTear meniscus heightmedicineHumansMeibomian Gland DysfunctionAgedLid marginReceiver operating characteristicbusiness.industryVisibility (geometry)Meibomian GlandsObjective methodMiddle AgedOphthalmologymedicine.anatomical_structureTearsEyelid DiseasesDry Eye Syndromessense organsbusinessOptometryOptometry and Vision Science
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Correlation between type 2 diabetes, dry eye and Meibomian glands dysfunction

2019

espanolObjetivo Evaluar las glandulas de Meibomio, la superficie ocular y la funcion de la lagrima en pacientes con diabetes tipo 2, y estudiar la correlacion entre estas situaciones. Metodos Estudio prospectivo de 76 varones, 37 de ellos con diabetes tipo 2, con una media de duracion de entre 7±5 anos, y 36 mujeres como grupo control. Tras completar el cuestionario del indice de enfermedad de la superficie ocular (OSDI), se obtuvieron el tiempo de ruptura lagrimal no invasivo (NIBUT) y el patron de la capa lipidica de la lagrima utilizando interferometria y altura del menisco lagrimal/AML. Se estudio la superficie ocular con tincion verde de lisamina y la morfologia de las glandulas con ev…

MaleOriginal articlemedicine.medical_specialtyLightNIBUTDry eyeMeibomian glandType 2 diabetesOptometriaLinea03 medical and health sciences0302 clinical medicineSurveys and QuestionnairesmedicineHumansOcular Surface Disease IndexIn patientProspective StudiesInverse correlationLid marginGynecologyDiabetisbusiness.industryMarx's lineLínea de MarxDiabetesMiddle AgedMeibomian gland dysfunctionMeibomian secretionmedicine.diseaseInterferometrymedicine.anatomical_structureDiabetes Mellitus Type 2TearsOjo seco030221 ophthalmology & optometryDry Eye SyndromesDisfunción de la glándula de Meibomiosense organsbusiness030217 neurology & neurosurgeryOptometryJournal of Optometry
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Tear <sup>1</sup>H Nuclear Magnetic Resonance-Based Metabolomics Application to the Molecular Diagnosis of Aqueous Tear Deficiency and Me…

2020

<b><i>Purpose:</i></b> Meibomian gland dysfunction (MGD) is a major cause of signs and symptoms related to dry eyes (DE) and eyelid inflammation. We investigated the composition of human tears by metabolomic approaches in patients with aqueous tear deficiency and MGD. <b><i>Methods:</i></b> Participants in this prospective, case-control pilot study were split into patients with aqueous tear deficiency and MGD (DE-MGD [<i>n</i> = 15]) and healthy controls (CG; <i>n</i> = 20). Personal interviews, ocular surface disease index (OSDI), and ophthalmic examinations were performed. Reflex tears collected by capillarity were pr…

business.industryDry eyesMeibomian gland dysfunctionAqueous tear deficiencyGeneral Medicinemedicine.diseaseSensory Systems03 medical and health sciencesCellular and Molecular NeuroscienceOphthalmology0302 clinical medicineNuclear magnetic resonanceMetabolomicsmedicine.anatomical_structure030221 ophthalmology & optometrymedicineProton NMRTearsOcular Surface Disease Indexsense organsEyelidbusiness030217 neurology & neurosurgeryOphthalmic Research
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